Elite eight: Louisville, West Virginia; UConn, Mizzou; Pitt, Duke; UNC, Syracuse. [Five from Big East; two ACC; one Big 12]
Final four: Louisville; UConn; Duke; UNC
Championship game: Louisville v. UNC
There are some problematic or questionable games in my bracket (most notably, I have Maryland beating Memphis; Mizzou beating Marquette; West Virginia beating Michigan State; and I don't feel good about a potential Louisville-Wake Forest match-up depending on which WFU team shows up). I don't feel good about UNC if Lawson is really truly hurt (he looked okay against Duke in the final game of the season). And I do feel like a bit of a homer picking Louisville (although not as bad as my Duke friends, who pick the Dookies every year).
However, I feel good about Louisville because they play the most tenacious defense of anyone and that defense does not depend upon one key player (like UConn). I think Thabeet will get in real foul trouble in a game (as he did against Pitt and as he did in the overtime against Syracuse); because UConn's defense relies on him protecting the rim, when he goes out, a team like Louisville can really attack the basket. Louisville, on the other hand, plays eleven guys and their team doesn't rely on one, not even Terrance Williams. Hence, my pick.